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Caroline FONTA

Directeur de Recherche 2ème classe CNRS

Tél : (+33)(0)5-62-74-61-51

Fax : (+33)(0)5-62-74-61-17

IMPEC (Images et Modèles Pour l’Exploration du Cerveau)

Who I am :

CNRS Research Director (DR2), CerCo (Brain and Cognition Research Center )(CNRS-UT3), TMBI (Univ. Toulouse), in the IMPEC group (Images et Modèles Pour l’Exploration du Cerveau). After a first scientific life studying the anatomo-functional organization of the olfactory system in invertebrates, I joined the CerCo in 1993 to work on the primate cerebral cortex postnatal development with Pr Michel Imbert, with an emphasis on the organization of the cortical microvascular network in marmosets. I am currently developing the marmoset monkey model to investigate normal and pathological brain aging processes, using multimodal brain imaging. I am also originally exploring the alkaline phosphatase functions in neurotransmission. I work in strong collaborations in Toulouse with chemists (LSPCMIB), experts in image analysis and statistics (Toulouse Mathematics Institute, IMT) and in fluid dynamics (Institute of Fluid Mechanics (IMFT).

Key words : cortex, multimodal brain imaging, vascularization, modular organization, microcirculation, multi-scale, TNAP, metabolites, neurotransmission, postnatal development, aging, pathologies, primate, marmoset, transgenic mice.

Technics : Histology, immunohistochemistry, microscopy, XR micro-tomography, brain imaging (NMR, PET, SPECT).

Current PhD students

  • Marie GLEIZES (2014-2017) co-direction L Nowak (CerCo) ; ED CLESCO Toulouse Ectonucleotidases, adenosine and synaptic transmission.
  • Simon PERRIER (2015-2018) co-direction L Nowak (CerCo) ; ED CLESCO Toulouse Control of signal transfert by adenosine in the cortex.

Short CV

Cursus Engineer in Agronomy, I obtained a Master degree in Entomology at University Paris 6 (grant INRA). My PhD , Entomology option Physiology, was obtained in 1984 at University Paris 6 (grant DGRST) ‘La communication chimique chez le bourdon : une approche neurobiologique pluridisciplinaire’ under the supervision of Dr Claudine Masson. My Habilitation à Diriger des Recherches (HDR), University Toulouse 3, was defended in 2003.

Professional experience

  • 1985 : Postdoctoral position, Zoology Dpt, University of Cambridge, UK (grant British Council) Sensori-motor system, Invertebrates, Electrophysiology
  • 1986-1993 : Junior Scientist CNRS, Laboratory of Comparative Neurobiology in Invertebrates INRA-CNRS (Bures/Yvette). Sensory physiology, Chemical communication Electrophysiology, Neuroanatomy, Behaviour.
  • 1993-present : Senior Scientist, CerCo (see above)

Awards Prix de La Recherche 2008, mention Human Health, Les Lauriers de la Recherche de la Ville de Toulouse 2009.

Recent selected publications (5 last years)

  • Guibert R, Fonta C, Plouraboué F 2010. Cerebral blood flow modeling in primate cortex. Journal of Cerebral Blood Flow and Metabolism 30(11) : 1860-1873.
  • Guibert R, Fonta C, Risser L, Plouraboué F 2012. Coupling and robustness of intra-cortical vascular territories. NeuroImage 62:408-417.
  • Guibert R, Fonta C, Estève F, Plouraboué F 2013. On the normalization of cerebral blood flow. Cerebral Blood Flow and Metabolism 33:669-672.
  • Risser L, Dolius L, Fonta C, Mescam M. 2014. Diffeomorphic registration with self-adaptive spatial regularization for the segmentation of non-human primate brains. IEEE Engineering in Medicine and Biology Society. 6695-6698.
  • Salabert AS, Fonta C, Fontan C, Adel D, Alonso M, Pestourie C, Belhadj-Tahar H, Tafani M, Payoux P. 2015. Radiolabeling of [18F]-fluoroethylnormemantine and initial in vivo evaluation of this innovative PET tracer for imaging the PCP sites of NMDA receptors. Nuclear Medicine and Biology 42 : 643-653.
  • Sadoun A, Strelnikov K, Bonté E, Fonta* C, Girard* P 2015. Cognitive impairment in a young marmoset reveals lateral ventriculomegaly and a mild hippocampal atrophy : a case report. Scientific Reports Nov 3 ;5:16046. doi : 10.1038/srep16046. *equal contribution.
  • Caroline Fonta and László Négyessy (Eds) 2015. Neuronal Tissue-Nonspecific Alkaline Phosphatase (TNAP), Subcellular Biochemistry, Vol. 76. Springer ISBN 978-94-017-7196-2, DOI 10.1007/978-94-017-7197-9. 350pp.

All publications

  • Fonta C and Masson C. 1982. Analyse de l’équipement sensoriel antennaire du Bourdon Bombus hypnorum L. Apidologie 13(3) : 247-263.
  • Pham M-H, Fonta C and Masson C. 1983. L’apprentissage olfactif de l’Abeille et le Bourdon : une étude comparée par conditionnement associatif. C. R. Acad. Sc. Paris serie III 296 : 501-506.
  • Fonta C and Masson C. 1984. Comparative study by electrophysiology of olfactory responses in bumblebees (Bombus hypnorum and Bombus terrestris). Journal of Chemical Ecology 10(8) : 1157-1168.
  • Genin E, Jullien R, Perez F, Fonta C and Masson C. 1984. Données préliminaires sur les médiateurs chimiques du Bourdon Bombus hypnorum (Hymenoptère, Apoïde, Bombinae). C.R. Acad. Sc. Paris, serie III 299(8) : 297-302.
  • Fonta C and Masson C. 1985. Organisation neuroanatomique de la voie afférente antennaire chez les Bourdons mâles et femelles (Bombus sp.). C. R. Acad. Sc. Paris serie III 300(11) : 437-442.
  • Fonta C, Pham-Delegue M-H, Marilleau R and Masson C. 1985. Rôle des nectars de tournesol dans le comportement des insectes pollinisateurs et analyse qualitative et quantitative des éléments glucidiques de ces secrétions. Acta Oecologica Oecologia Applicata 6(2) : 175-186.
  • Delabie J, Bos C, Fonta C and Masson C. 1985. Toxic and repellent effects of Cypermethrin on the honeybee : laboratory, glasshouse and field experiments. Pestic. Sci. 16 : 409-415.
  • Pham-Delegue M-H, Fonta C, Masson C and Douault P. 1985. Etude comparée du comportement de butinage d’insectes pollinisateurs (abeilles domestiques Apis mellifica L. et bourdons Bombus terrestris L.) sur les lignées parentales d’hybrides de tournesol Helianthus annuus L. Acta Oecologica Oecologia Applicata 6(1) : 47-67.
  • Fonta C and Masson C. 1987. Structural and functional studies of the peripheral olfactory nervous system of male and female bumble-bees (Bombus hypnorum and Bombus terrestris). Chemical Senses 12(1) : 53-69.
  • Fonta C, Sun X-J and Masson C. 1993. Morphology and spatial distribution of bee antennal lobe interneurones responsive to odours. Chemical Senses 18(2) : 101-119.
  • Sun X-J, Fonta C and Masson C. 1993. Odour quality processing by bee antennal lobe interneurones. Chemical Senses 18(4) : 355-377.
  • Masson C, Pham-Delegue M-H, Fonta C, Gascuel J, Arnold G, Nicolas G and Kerszberg M. 1993. Recent advances in the concept of adaptation to natural odour signals in the honeybee, Apis mellifera L. Apidologie 24 : 169-194.
  • Fonta C, Gascuel J and Masson C. 1995. Brain FOS-like expression in developing and adult honeybees. Neuroreport 6(5) : 745-749.
  • Deguine O, Chappert C, Fonta C and Imbert I. 1996. Prenatal lesioning of vestibular organ by aminoglycosides. NeuroReport 7(15-17) : 2435-2438.
  • Fonta C, Chappert C and Imbert M. 1997. NMDAR1 involvement in the postnatal organization of the primary visual cortex of Callithrix jacchus. The Journal of Comparative Neurology 386(2) : 260-276.
  • Uro-Coste E, Fonta C, Hatey F, Perret E, Delisle MB, Caput D and Imbert M. 1997. Expression of SKP1 mRNA and protein in rat brain during post-natal development. NeuroReport 8 : 1675-1678.
  • Uro-Coste E, Perret E, Fonta C, Mathieu M, Delisle M-B, Caput D and Imbert M. 1998. The cell cycle SKP1 is regulated by light in postnatal rat brain. Molecular Brain Research 56 : 192-199.
  • Fonta C, Chappert C and Imbert M. 2000. Effect of monocular deprivation on NMDAR1 immunostaining in ocular dominance columns of the marmoset Callithrix jacchus. Visual Neuroscience 17 : 345-352.
  • Chappert-Piquemal C, Fonta C, Malecaze F and Imbert M. 2001. Ocular dominance columns in the adult New World Monkey Callithrix jacchus. Visual Neuroscience 18 : 407-412.
  • Fonta C, Imbert M. 2002. Vascularization in the primate visual cortex during development. Cerebral Cortex 12 : 199-211.
  • Fonta C, Negyessy L, Renaud L, Barone P. 2004. Areal and subcellular localization of the ubiquitous alkaline phosphatase in the primate cerebral cortex : evidence for a role in neurotransmission. Cerebral Cortex 14(6):595-609.
  • Plouraboué F, Cloetens P, Fonta C, Steyer A, Lauwers F, Marc-Vergnes JP. 2004. X-ray high-resolution vascular network imaging. Journal of Microscopy 215(Pt 2):139-148.
  • Fonta C, Negyessy L, Renaud L, Barone P. 2005. Postnatal development of Alkaline Phosphatase activity correlates with the maturation of neurotransmission in the cerebral cortex. The Journal of Comparative Neurology 486:179-196.
  • Laffont-Proust I, Hässig R, Haïk S, Simon S, Grassi J, Fonta C, Faucheux BA, Moya KL 2006. Truncated PrPc in mammalian brain : interspecies variation and location in membrane rafts. Biological Chemistry 387:297-300.
  • Risser L, Plouraboué F, Steyer A, Cloetens P, Le Duc G, Fonta C 2007. From homogeneous to fractal normal and tumorous microvascular networks in the brain. Journal of Cerebral Blood Flow and Metabolism 27(2) :293-303.
  • Laffont-Proust I, Fonta C, Renaud L, Hässig R, Moya KL 2007. Developmental changes in PrPc in primate visual cortex. The Journal of Comparative Neurology 504:646-658.
  • Risser L, Plouraboué F, Cloetens P, Fonta C 2009. A 3D-investigation shows that angiogenesis in primate cerebral cortex mainly occurs at capillary level. International Journal of Developmental Neuroscience 27:185-196.
  • Guibert R, Fonta C, Plouraboué F 2009. Le réseau microvasculaire structure la distribution de la pression sanguine. Mécanique et Industries 10:255-260.
  • Serduc R, Bouchet A, Braüer-Krisch E, Laissue JA, Spiga J, Sarun S, Bravin A, Fonta C, Renaud L, Boutonnat J, Siegbahn EA, Estève F, Le Duc G. 2009. Synchrotron microbeam radiation therapy for rat brain tumor palliation – influence of the microbeam width at constant valley dose. Physics in Medicine and Biology 54 : 6711-6724.
  • Guibert R, Fonta C, Plouraboué F 2010. A new approach to model confined suspensions flows in complex networks : application to blood flow. Transport in Porous Media 83(1) : 171-194.
  • Guibert R, Fonta C, Plouraboué F 2010. Cerebral blood flow modeling in primate cortex. Journal of Cerebral Blood Flow and Metabolism 30(11) : 1860-1873.
  • Descombes X, Plouraboué F, El Boustani H, Fonta C, LeDuc G, Serduc R, Weitkamp T. 2011. Brain tumor vascular network segmentation from micro-tomography. IEEE 8th International Symposium on Biomedical Imaging : from nano to macro : 1113-1116.
  • Négyessy L, Xiao JS, Kantor O, Kovacs GG, Palkovits M, Doczi TP, Renaud L, Baksa G, Glasz T, Ashaber M, Barone P, Fonta C 2011. Layer-specific activity of Tissue Non-specific Alkaline Phosphatase in the human neocortex. Neuroscience 172 :406-418.
  • Brun-Heath I, Ermoval M, Chabrol E, Xiao JS, Palkovits M, Lyck, R, Miller F, Couraud PO, Mornet E, Fonta C 2011. Differential expression of the bone and the liver Tissue Non-specific Alkaline Phosphatase isoforms in brain tissues. Cell and Tissue Research 343:521-536.
  • Descombes X, Plouraboué F, El Boustani H, Fonta C, LeDuc G, Serduc R, Weitkamp T. 2012. Vascular Network Segmentation : An Unsupervised Approach. IEEE 9th International Symposium on Biomedical Imaging (ISBI) : 1248-1251.
  • Guibert R, Fonta C, Risser L, Plouraboué F 2012. Coupling and robustness of intra-cortical vascular territories. NeuroImage 62:408-417.
  • Hanics J, Barna L, Xiao JS, Millan JL, Fonta C*, Négyessy L* 2012. Ablation of TNAP gene compromises myelination and synaptogenesis in the brain. Cell and Tissue Research 349(2):459-471(* equal contribution).
  • Fonta C, Negyessy L, Brun Heath I, Ermonval M, Czege D, Nowak LG, Frances B, Xiao JS, Mornet E, Millan JL. 2012. Bone TNAP in the brain : functions in neurotransmission. Bull Group Int Rech Sci Stomatol Odontol 51(1):e27.
  • Descombes X, Malandain G, Fonta C, Negyessy L, Mosko R. 2013 Automatic dendrite spines detection from X-Ray tomography volumes. IEEE 10th International Symposium on Biomedical Imaging (ISBI) : from nano to macro : 436-439.
  • Guibert R, Fonta C, Estève F, Plouraboué F 2013. On the normalization of cerebral blood flow. Cerebral Blood Flow and Metabolism 33:669-672.
  • Kántor O, Varga A, Kovács-Öller T, Énzsöly A, Balogh L, Baksa G, Szepessy Z, Fonta, C, Szél Á, Négyessy L, Völgyi B, Lukáts Á. 2014 TNAP activity is localized at critical sites of retinal neurotransmission across various vertebrate species. Cell and Tissue Research 358,1:85-98.
  • Salabert AS, Alonso M, Adel D, Pottier V, Tafani M, Fonta C, Payoux P. 2014. Synthesis and binding analysis in rat brain of 18[F]-FNM (Fluoroethylnormemantine):towards an innovative PET tracer to image activated NMDA receptors Nuclear Medecine and Molecular Imaging, 41 (2) suppl:OP224.
  • Risser L, Dolius L, Fonta C, Mescam M. 2014. Diffeomorphic registration with self-adaptive spatial regularization for the segmentation of non-human primate brains. IEEE Engineering in Medicine and Biology Society : 6695-6698.
  • Salabert AS, Fonta C, Fontan C, Adel D, Alonso M, Pestourie C, Belhadj-Tahar H, Tafani M, Payoux P. 2015. Radiolabeling of [18F]-fluoroethylnormemantine and initial in vivo evaluation of this innovative PET tracer for imaging the PCP sites of NMDA receptors. Nuclear Medicine and Biology 42 : 643-653.
  • Sadoun A, Strelnikov K, Bonté E, Fonta* C, Girard* P 2015. Cognitive impairment in a young marmoset reveals lateral ventriculomegaly and a mild hippocampal atrophy : a case report. Scientific Reports Nov 3 ;5:16046. doi : 10.1038/srep16046. *equal contribution.
  • Estève D, Galitzky J, Bouloumié A, Fonta C, Buchet R, Magne D. 2016. Multiple functions of MSCA-1/TNAP in adult mesenchymal progenitor/stromal cells. Stem Cells International vol. 2016, doi:10.1155/2016/1815982, 8 pages.

Main present collaborations

  • Lionel Nowak, Pascal Girard, Muriel Mescam, Florence Rémy, Nathalie Vayssière, Kuzma Strelnikov (CerCo)
  • Pierre Payoux, Anne-Sophie Brun-Salabert, INSERM U1214 TONIC, Toulouse
  • Laurent Risser, Institut de Mathématiques de Toulouse
  • Franck Plouraboué, Moktar Zagzoule, Patricia Cathalifaud, Institut de Mécanique des Fluides de Toulouse (IMFT)
  • Jose Luis Millan, Burnham Institute, La Jolla, USA
  • Laszo Négyessy, Complex Systems and Computational Neuroscience Group, Hungarian Academy of Sciences, Budapest, Hongrie.
  • Etienne Mornet, Laboratoire de Génétique Constitutionnelle, Centre Hospitalier, Versailles
  • Myriam Ermonval, Stratégies antivirales, Institut Pasteur Paris
  • David Magne, ICBMS, Université Claude Bernard, Lyon, France
  • Myriam Martino, Véronique Gilard, Groupe de RMN biomédicale, LSPCMIB, Toulouse
  • Jean Pierre Salles, CPTP, Hôpital des Enfants Purpan, Toulouse

Mise à jour 27/03/2016